翻訳と辞書 Words near each other ・ Dnieper–Bug Canal ・ DNA Tower ・ DNA unwinding element ・ DNA vaccination ・ DNA virus ・ DNA-(apurinic or apyrimidinic site) lyase ・ DNA-3-methyladenine glycosylase ・ DNA-3-methyladenine glycosylase I ・ DNA-3-methyladenine glycosylase II ・ DNA-binding domain ・ DNA-Binding Metallo-intercalators ・ DNA-binding protein ・ DNA-binding protein from starved cells ・ DNA-deoxyinosine glycosylase ・ DNA-directed DNA polymerase ・ DNA-directed RNA interference ・ DNA-encoded chemical library ・ DNA-formamidopyrimidine glycosylase ・ DNA-Functionalized Quantum Dots ・ DNA-PKcs ・ DNA-SCARS ・ DNA/RNA non-specific endonuclease ・ DNA2.0 ・ DNA2L ・ DNAA ・ DnaA ・ DnaB ・ DnaB helicase ・ DnaC ・ DnaD Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク DNA-directed RNA interference ： ウィキペディア英語版 DNA-directed RNA interference DNA-directed RNA interference (ddRNAi) is a gene-silencing technique that utilizes DNA constructs to activate an animal cell’s endogenous RNA interference (RNAi) pathways. DNA constructs are designed to express self-complementary double-stranded RNAs, typically short-hairpin RNAs (shRNA), that once processed bring about silencing of a target gene or genes. Any RNA, including endogenous mRNAs or viral RNAs, can be silenced by designing constructs to express double-stranded RNA complementary to the desired mRNA target. This mechanism has great potential as a novel therapeutic to silence disease-causing genes. Proof-of-concept has been demonstrated across a range of disease models, including viral diseases such as HIV, hepatitis B or hepatitis C, or diseases associated with altered expression of endogenous genes such as drug-resistant lung cancer, neuropathic pain, advanced cancer and retinitis pigmentosa. == ddRNAi mechanism == As seen in Figure 1, a ddRNAi construct encoding an shRNA is packaged into a delivery vector or reagent tailored to target specific cells. Inside the cell, the DNA is transported to the nucleus where transcription machinery continually manufactures the encoded RNAs. The shRNA molecules are then processed by endogenous systems and enter the RNAi pathway and silence the desired genes.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「DNA-directed RNA interference」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.